Ceremonial Cacao
Cacao was used before Mesoamerica took it up: in 2018 Sonia Zarrillo's team reported cacao starch, theobromine and ancient DNA about 5,300 years old at Santa Ana-La Florida in south-east Ecuador.
Sonia Zarrillo et al., 'The use and domestication of Theobroma cacao during the mid-Holocene in the upper Amazon', Nature Ecology & Evolution 2 (2018), 1879–1888
Raw cacao prepared and drunk in a ritual setting, marketed today as an ancient Maya spiritual practice.